abstract：BACKGROUND:Tissue Doppler index E/e' is used clinically and in multidisciplinary research for estimation of left ventricular filling pressure (LVFP) and diastolic dysfunction (DD)/heart failure with preserved ejection fraction (HFpEF). Its diagnostic accuracy is not well studied. METHODS AND RESULTS:From the PubMed, S...

journal_title：Journal of the American Heart Association

authors： Sharifov OF,Schiros CG,Aban I,Denney TS,Gupta H

更新日期：2016-01-25 00:00:00

abstract：BACKGROUND:Galectin-3 may play a role in cardiac and noncardiac fibrosis, and elevated circulating levels of this protein predict adverse outcomes in patients with heart failure who do not have congenital heart disease. We investigated galectin-3 in adults with single-ventricle Fontan circulation, patients who are pron...

journal_title：Journal of the American Heart Association

authors： Opotowsky AR,Baraona F,Owumi J,Loukas B,Singh MN,Valente AM,Wu F,Cheng S,Veldtman G,Rimm EB,Landzberg MJ

更新日期：2016-01-11 00:00:00

abstract：BACKGROUND:Stroke is a leading cause of death in the world. In >80% of strokes, the initial acute phase of ischemic injury is due to the occlusion of a blood vessel resulting in severe focal hypoperfusion, excitotoxicity, and oxidative damage. Interferon-β (IFNβ), a cytokine with immunomodulatory properties, was approv...

journal_title：Journal of the American Heart Association

authors： Kuo PC,Scofield BA,Yu IC,Chang FL,Ganea D,Yen JH

更新日期：2016-01-08 00:00:00

abstract：BACKGROUND:In 2013 the Minnesota Resuscitation Consortium developed an organized approach for the management of patients resuscitated from shockable rhythms to gain early access to the cardiac catheterization laboratory (CCL) in the metro area of Minneapolis-St. Paul. METHODS AND RESULTS:Eleven hospitals with 24/7 per...

journal_title：Journal of the American Heart Association

authors： Garcia S,Drexel T,Bekwelem W,Raveendran G,Caldwell E,Hodgson L,Wang Q,Adabag S,Mahoney B,Frascone R,Helmer G,Lick C,Conterato M,Baran K,Bart B,Bachour F,Roh S,Panetta C,Stark R,Haugland M,Mooney M,Wesley K,Yan

更新日期：2016-01-07 00:00:00

abstract：BACKGROUND:Heart failure is a highly prevalent cardiovascular complication among patients receiving long-term hemodialysis, but the benefits of carvedilol, bisoprolol, and metoprolol controlled release/extended release on the outcomes of these patients remain unclear. In this study, we address the use of these 3 β-bloc...

journal_title：Journal of the American Heart Association

authors： Tang CH,Wang CC,Chen TH,Hong CY,Sue YM

更新日期：2016-01-06 00:00:00

abstract：BACKGROUND:Preeclampsia (PE) is a life-threatening hypertensive disorder of pregnancy associated with autoantibodies, termed AT1-AA, that activate the AT1 angiotensin receptor. Although the pathogenic nature of these autoantibodies has been extensively studied, little is known about the molecular cause of their generat...

journal_title：Journal of the American Heart Association

authors： Liu C,Luo R,Elliott SE,Wang W,Parchim NF,Iriyama T,Daugherty PS,Blackwell SC,Sibai BM,Kellems RE,Xia Y

更新日期：2015-12-16 00:00:00

abstract：BACKGROUND:Perioperative antiplatelet agents potentially increase bleeding after non-ST-segment elevation (NSTE) acute coronary syndromes (ACS). The protease-activated receptor 1 antagonist vorapaxar reduced cardiovascular events and was associated with increased bleeding versus placebo in NSTE ACS, but its efficacy an...

journal_title：Journal of the American Heart Association

authors： van Diepen S,Tricoci P,Podder M,Westerhout CM,Aylward PE,Held C,Van de Werf F,Strony J,Wallentin L,Moliterno DJ,White HD,Mahaffey KW,Harrington RA,Armstrong PW

更新日期：2015-12-15 00:00:00

abstract：BACKGROUND:To address the lack of knowledge regarding the long-term risk of intracranial hemorrhage (ICH) after acute myocardial infarction (AMI), the aims of this study were to: (1) investigate the incidence, time trends, and predictors of ICH in a large population within 1 year of discharge after AMI; (2) investigate...

journal_title：Journal of the American Heart Association

authors： Graipe A,Binsell-Gerdin E,Söderström L,Mooe T

更新日期：2015-12-11 00:00:00

abstract：BACKGROUND:Although automated external defibrillators (AEDs) have contributed to a better survival of out-of-hospital cardiac arrests, there have been reports of their malfunctioning. We investigated the diagnostic accuracy of commercially available AEDs using surface ECGs of ventricular fibrillation (VF), ventricular ...

journal_title：Journal of the American Heart Association

authors： Nishiyama T,Nishiyama A,Negishi M,Kashimura S,Katsumata Y,Kimura T,Nishiyama N,Tanimoto Y,Aizawa Y,Mitamura H,Fukuda K,Takatsuki S

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Middle-aged adults with ideal blood pressure, cholesterol, and glucose levels exhibit substantially lower cardiovascular mortality than those with unfavorable levels. Four healthy lifestyle components-optimal body weight, diet, physical activity, and not smoking-are recommended for cardiovascular health (CVH...

journal_title：Journal of the American Heart Association

authors： Gooding HC,Shay CM,Ning H,Gillman MW,Chiuve SE,Reis JP,Allen NB,Lloyd-Jones DM

更新日期：2015-10-29 00:00:00

abstract：BACKGROUND:There are few data relating novel measures of left ventricular (LV) mechanical function to cardiovascular disease (CVD) outcomes in the community. Whether distinct components of LV mechanical function provide information regarding risk for different CVD outcomes is unclear. METHODS AND RESULTS:We used speck...

journal_title：Journal of the American Heart Association

authors： Cheng S,McCabe EL,Larson MG,Merz AA,Osypiuk E,Lehman BT,Stantchev P,Aragam J,Solomon SD,Benjamin EJ,Vasan RS

更新日期：2015-10-27 00:00:00

abstract：BACKGROUND:Optimal thromboprophylaxis after cardiac surgery is uncertain. This systematic review aimed to define the incidence and risk factors for deep vein thrombosis (DVT), fatal and nonfatal pulmonary embolism (PE), and assess whether venous thromboembolism (VTE) prophylaxis was effective in reducing VTE without co...

journal_title：Journal of the American Heart Association

authors： Ho KM,Bham E,Pavey W

更新日期：2015-10-26 00:00:00

abstract：BACKGROUND:Transcription of the myristoylated alanine-rich C kinase substrate (MARCKS) is upregulated in animal models of intimal hyperplasia. MARCKS knockdown inhibits vascular smooth muscle cell (VSMC) migration in vitro; however, the mechanism is as yet unknown. We sought to elucidate the mechanism of MARCKS-mediate...

journal_title：Journal of the American Heart Association

authors： Yu D,Makkar G,Strickland DK,Blanpied TA,Stumpo DJ,Blackshear PJ,Sarkar R,Monahan TS

更新日期：2015-10-08 00:00:00

abstract：BACKGROUND:Physical activity is of benefit for primary prevention of cardiovascular diseases, but it appears to increase the risk for atrial fibrillation. We aimed to study a cohort of patients following a first stroke in individuals with previous high physical activity, compare them to the general population with resp...

journal_title：Journal of the American Heart Association

authors： Hållmarker U,Åsberg S,Michaëlsson K,Ärnlöv J,Hellberg D,Lindbäck J,Wester P,James S

更新日期：2015-09-24 00:00:00

abstract：BACKGROUND:Cardiovascular disease is the leading cause of death in the United States, making improving cardiovascular health a key population health goal. As part of efforts to achieve this, the American Heart Association has developed the first comprehensive cardiovascular health index (CVHI). Our objective was to inv...

journal_title：Journal of the American Heart Association

authors： Pilkerton CS,Singh SS,Bias TK,Frisbee SJ

更新日期：2015-09-22 00:00:00

abstract：BACKGROUND:Several cross-sectional, but few prospective, studies suggest that inflammation may be involved in the development of hypertension. We examined markers of inflammation-high-sensitivity C-reactive protein, interleukin-6, and soluble intercellular adhesion molecule-1-and a marker of fibrinolysis, D-dimer, for ...

journal_title：Journal of the American Heart Association

authors： Sesso HD,Jiménez MC,Wang L,Ridker PM,Buring JE,Gaziano JM

更新日期：2015-09-21 00:00:00

abstract：BACKGROUND:Impacts of a single radiofrequency ablation (RFA) on quality of life (QoL) were not well investigated in atrial fibrillation (AF) patients with low stroke risk. METHODS AND RESULTS:Nine hundred AF patients with low CHADS2 score (ie, CHADS2 ≤1) who completed both a baseline and 6-month Atrial Fibrillation Ef...

journal_title：Journal of the American Heart Association

authors： Bai Y,Bai R,Wu JH,Zhang T,Liu N,Shi XB,Liu XY,Liu XH,Du X,Dong JZ,Ma CS

更新日期：2015-09-16 00:00:00

abstract：BACKGROUND:CSL112 is a new formulation of human apolipoprotein A-I (apoA-I) being developed to reduce cardiovascular events following acute coronary syndrome. This phase 2a, randomized, double-blind, multicenter, dose-ranging trial represents the first clinical investigation to assess the safety and pharmacokinetics/ph...

journal_title：Journal of the American Heart Association

authors： Tricoci P,D'Andrea DM,Gurbel PA,Yao Z,Cuchel M,Winston B,Schott R,Weiss R,Blazing MA,Cannon L,Bailey A,Angiolillo DJ,Gille A,Shear CL,Wright SD,Alexander JH

更新日期：2015-08-25 00:00:00

abstract：BACKGROUND:Diabetes is associated with coronary arteriolar endothelial dysfunction. We investigated the role of the small/intermediate (SK(Ca)/IK(Ca)) conductance of calcium-activated potassium channels in diabetes-related endothelial dysfunction. METHODS AND RESULTS:Coronary arterioles (80 to 150 μm in diameter) were...

journal_title：Journal of the American Heart Association

authors： Liu Y,Xie A,Singh AK,Ehsan A,Choudhary G,Dudley S,Sellke FW,Feng J

更新日期：2015-08-24 00:00:00

abstract：BACKGROUND:Little is known about the hemodynamic response to exercise in heart failure patients at various ages before and after heart transplantation (HT). This information is important because postoperative hemodynamics may be a predictor of survival. To investigate the hemodynamic response to HT and exercise, we gro...

journal_title：Journal of the American Heart Association

authors： Lundgren J,Rådegran G

更新日期：2015-07-21 00:00:00

abstract：BACKGROUND:MYBPC3 dysfunctions have been proven to induce dilated cardiomyopathy, hypertrophic cardiomyopathy, and/or left ventricular noncompaction; however, the genotype-phenotype correlation between MYBPC3 and restrictive cardiomyopathy (RCM) has not been established. The newly developed next-generation sequencing m...

journal_title：Journal of the American Heart Association

authors： Wu W,Lu CX,Wang YN,Liu F,Chen W,Liu YT,Han YC,Cao J,Zhang SY,Zhang X

更新日期：2015-07-10 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging of carotid plaque can aid in stroke risk stratification in patients with carotid stenosis. However, the prevalence of complicated carotid plaque in patients with cryptogenic stroke is uncertain, especially as assessed by plaque imaging techniques routinely included in acute stroke ...

journal_title：Journal of the American Heart Association

authors： Gupta A,Gialdini G,Lerario MP,Baradaran H,Giambrone A,Navi BB,Marshall RS,Iadecola C,Kamel H

更新日期：2015-06-15 00:00:00

abstract：BACKGROUND:The volume-outcome relationship associated with intensive care unit (ICU) experience with managing acute myocardial infarction (AMI) remains inadequately understood. METHODS AND RESULTS:Within a multicenter clinical ICU database, we identified patients with a primary ICU admission diagnosis of AMI between 2...

journal_title：Journal of the American Heart Association

authors： Stolker JM,Badawi O,Spertus JA,Nasir A,Kennedy KF,Harris IH,Franey CS,Hsu VD,Ripple GR,Howell GH,Lem VM,Chan PS

更新日期：2015-06-11 00:00:00

abstract：BACKGROUND:Few studies have examined the impact of lifecourse socioeconomic position (SEP) on cardiovascular disease (CVD) risk among African Americans. METHODS AND RESULTS:We used data from the Jackson Heart Study (JHS) to examine the associations of multiple measures of lifecourse SEP with CVD events in a large coho...

journal_title：Journal of the American Heart Association

authors： Gebreab SY,Diez Roux AV,Brenner AB,Hickson DA,Sims M,Subramanyam M,Griswold ME,Wyatt SB,James SA

更新日期：2015-05-27 00:00:00

abstract：BACKGROUND:Natriuretic peptides promote natriuresis, diuresis, and vasodilation. Experimental deficiency of natriuretic peptides leads to hypertension (HTN) and cardiac hypertrophy, conditions more common among African Americans. Hospital-based studies suggest that African Americans may have reduced circulating natriur...

journal_title：Journal of the American Heart Association

authors： Gupta DK,Claggett B,Wells Q,Cheng S,Li M,Maruthur N,Selvin E,Coresh J,Konety S,Butler KR,Mosley T,Boerwinkle E,Hoogeveen R,Ballantyne CM,Solomon SD

更新日期：2015-05-21 00:00:00

abstract：BACKGROUND:Elevated serum phosphorus might aggravate the effect of hypertension on mortality. The objective of this study was to examine the joint effect of hypertension and serum phosphorus on the risk of mortality. METHODS AND RESULTS:A large prospective (n=15 833), population-based cohort of participants from the N...

journal_title：Journal of the American Heart Association

authors： Vart P,Nigatu YT,Jaglan A,van Zon SK,Shafique K

更新日期：2015-05-20 00:00:00

abstract：BACKGROUND:Cystathionine γ-lyase, cystathionine β-synthase, and 3-mercaptopyruvate sulfurtransferase are endogenous enzymatic sources of hydrogen sulfide (H2S). Functions of H2S are mediated by several targets including ion channels and signaling proteins. Nuclear factor-erythroid 2-related factor 2 is responsible for ...

journal_title：Journal of the American Heart Association

authors： Islam KN,Polhemus DJ,Donnarumma E,Brewster LP,Lefer DJ

更新日期：2015-05-14 00:00:00

abstract：BACKGROUND:Whether heart rate upon discharge following hospitalization for heart failure is associated with long-term adverse outcomes and whether this association differs between patients with sinus rhythm (SR) and atrial fibrillation (AF) have not been well studied. METHODS AND RESULTS:We conducted a retrospective c...

journal_title：Journal of the American Heart Association

authors： Laskey WK,Alomari I,Cox M,Schulte PJ,Zhao X,Hernandez AF,Heidenreich PA,Eapen ZJ,Yancy C,Bhatt DL,Fonarow GC,AHA Get With The Guidelines®‐Heart Failure Program.

更新日期：2015-04-22 00:00:00

abstract：BACKGROUND:Serum bicarbonate varies over time in chronic kidney disease (CKD) patients, and this variability may portend poor cardiovascular outcomes. The aim of this study was to conduct a time-updated longitudinal analysis to evaluate the association of serum bicarbonate with long-term clinical outcomes: heart failur...

journal_title：Journal of the American Heart Association

authors： Dobre M,Yang W,Pan Q,Appel L,Bellovich K,Chen J,Feldman H,Fischer MJ,Ham LL,Hostetter T,Jaar BG,Kallem RR,Rosas SE,Scialla JJ,Wolf M,Rahman M,CRIC Study Investigators.

更新日期：2015-04-20 00:00:00

abstract：BACKGROUND:Although guidelines for antiarrhythmic drug therapy in atrial fibrillation (AF) were published in 2006, it remains uncertain whether adherence to these guidelines affects patient outcomes. METHODS AND RESULTS:We retrospectively evaluated the records of 5976 consecutive AF patients who were prescribed at lea...

journal_title：Journal of the American Heart Association

authors： Qin D,Leef G,Alam MB,Rattan R,Munir MB,Patel D,Khattak F,Vaghasia N,Adelstein E,Jain SK,Saba S

更新日期：2015-04-06 00:00:00

abstract：BACKGROUND:Patients with normalized mean pulmonary artery pressure (mPAP) after pulmonary endarterectomy (PEA) for chronic thromboembolic pulmonary hypertension (CTEPH) do not always regain normal exercise capacity. We evaluated right ventricular function, its interaction with both pulsatile and resistive afterload, an...

journal_title：Journal of the American Heart Association

authors： Claessen G,La Gerche A,Dymarkowski S,Claus P,Delcroix M,Heidbuchel H

更新日期：2015-03-23 00:00:00

abstract：BACKGROUND:Experimental studies demonstrate that high aortic pressure in late systole relative to early systole causes greater myocardial remodeling and dysfunction, for any given absolute peak systolic pressure. METHODS AND RESULTS:We tested the hypothesis that late systolic hypertension, defined as the ratio of late...

journal_title：Journal of the American Heart Association

authors： Chirinos JA,Segers P,Duprez DA,Brumback L,Bluemke DA,Zamani P,Kronmal R,Vaidya D,Ouyang P,Townsend RR,Jacobs DR Jr

更新日期：2015-03-03 00:00:00

abstract：BACKGROUND:Long chain acyl-CoA synthetases (ACSL) catalyze long-chain fatty acids (FA) conversion to acyl-CoAs. Temporal ACSL1 inactivation in mouse hearts (Acsl1(H-/-)) impaired FA oxidation and dramatically increased glucose uptake, glucose oxidation, and mTOR activation, resulting in cardiac hypertrophy. We used unb...

journal_title：Journal of the American Heart Association

authors： Schisler JC,Grevengoed TJ,Pascual F,Cooper DE,Ellis JM,Paul DS,Willis MS,Patterson C,Jia W,Coleman RA

更新日期：2015-02-24 00:00:00

abstract：BACKGROUND:Though left ventricular mass (LVM) predicts cardiovascular events (CVD) and mortality in African Americans, limited data exists on factors contributing to change in LVM and its prognostic significance. We hypothesized that baseline blood pressure (BP) and body mass index (BMI) and change in these variables o...

journal_title：Journal of the American Heart Association

authors： Fox ER,Musani SK,Samdarshi TE,Taylor JK,Beard WL,Sarpong DF,Xanthakis V,McClendon EE,Liebson PR,Skelton TN,Butler KR,Mosley TH,Taylor H,Vasan RS

更新日期：2015-02-05 00:00:00

abstract：BACKGROUND:Reactive oxygen species (ROS) are associated with development of coronary artery disease (CAD). However, there's no useful biomarker of ROS in CAD. METHODS AND RESULTS:We recruited 395 consecutive CAD patients who were performed coronary angiography (262 male and 133 female, age 70.2±10), and we measured se...

journal_title：Journal of the American Heart Association

authors： Hirata Y,Yamamoto E,Tokitsu T,Kusaka H,Fujisue K,Kurokawa H,Sugamura K,Maeda H,Tsujita K,Kaikita K,Hokimoto S,Sugiyama S,Ogawa H

更新日期：2015-01-28 00:00:00

abstract：BACKGROUND:Beta-blockers (BB) are recommended in secondary prevention of acute myocardial infarction (AMI), but adherence to prescription medication is a recognized problem. Most literature on the consequences of poor adherence to prescribed BB is limited by the possibility of "healthy adherer bias" and better-designed...

journal_title：Journal of the American Heart Association

authors： Di Bartolomeo S,Marino M,Guastaroba P,Valent F,De Palma R

更新日期：2015-01-07 00:00:00

abstract：BACKGROUND:Biventricular pacing (CRT) shows clear benefits in heart failure with wide QRS, but results in narrow QRS have appeared conflicting. We tested the hypothesis that study design might have influenced findings. METHOD AND RESULTS:We identified all reports of CRT-P/D therapy in subjects with narrow QRS reportin...

journal_title：Journal of the American Heart Association

authors： Jabbour RJ,Shun-Shin MJ,Finegold JA,Afzal Sohaib SM,Cook C,Nijjer SS,Whinnett ZI,Manisty CH,Brugada J,Francis DP

更新日期：2015-01-06 00:00:00

abstract：BACKGROUND:The p.Gln554X mutation in desmocollin-2 (DSC2) is prevalent in ≈10% of the Hutterite population. While the homozygous mutation causes severe biventricular arrhythmogenic right ventricular cardiomyopathy, the phenotypic features and prognosis of heterozygotes remain incompletely understood. METHODS AND RESUL...

journal_title：Journal of the American Heart Association

authors： Wong JA,Duff HJ,Yuen T,Kolman L,Exner DV,Weeks SG,Gerull B

更新日期：2014-12-11 00:00:00

abstract：BACKGROUND:Hypertension is a frequent risk factor for the development of heart failure with preserved ejection fraction (HFPEF). Progressive extracellular matrix accumulation has been presumed to be the fundamental pathophysiologic mechanism that leads to the transition to impaired diastolic reserve. However, the contr...

journal_title：Journal of the American Heart Association

authors： van Empel VP,Mariani J,Borlaug BA,Kaye DM

更新日期：2014-12-02 00:00:00

abstract：BACKGROUND:Peripheral arterial disease (PAD) shares several risk factors with atrial fibrillation (AF), and persons with PAD have an increased risk of stroke. It is unclear if PAD is associated with an increased risk for AF and whether this potential association explains the increased risk of stroke observed in those w...

journal_title：Journal of the American Heart Association

authors： O'Neal WT,Efird JT,Nazarian S,Alonso A,Heckbert SR,Soliman EZ

更新日期：2014-11-17 00:00:00